Kim HJ, et al. - Given that reactive oxygen species modulator-1 (Romo1) is a protein that modulates levels of reactive oxygen species (ROS) and has been reported to affect cancer cell invasion and proliferation via persistent inflammation, researchers examined the mechanism by which Romo1 adversely affects the prognosis of patients with non-small cell lung cancer (NSCLC). They tested Romo1, ROS, and vascular endothelial growth factor (VEGF) in tumor tissues immunohistochemically. According to the findings, Romo1 induces lymphatic metastasis of NSCLC by modulating persistent inflammation and oxidative stress (ROS)/VEGF signaling. Data reported that lymphatic metastasis correlated with elevated Romo1 was appeared to be a key reason for unfavorable survival rates.