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Overexpression of EI2BL promoted human non-small cell lung cancer progression by inducing cell EMT phenotype

Journal of Clinical Pathology Feb 27, 2020

Li HR, et al. - This study was carried out to assess the role of EI2BL in non-small cell lung cancer (NSCLC) and the association between expression of EI2BL and the prognosis of patients with NSCLC. Researchers applied immunohistochemistry, western blot analysis, immunofluorescence and real-time quantitative PCR (RT-qPCR) to assess EI2BL protein and mRNA levels in NSCLC and corresponding peritumoral tissues. They applied cell counting Kit-8, transwell assay and wound healing assay to examine the abilities of cell proliferation, invasion, and migration. This research showed that raised expression of EI2BL promoted NSCLC cell proliferation, migration and invasion, and EI2BL overexpression may be a reliable biomarker of poor prognosis.
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