Wang F, Shu X, Meszoely I, et al. - Via a large cohort study of 16,025 male and 1,800,708 female patients with breast cancer in the United States, researchers contrasted mortality between male and female patients with breast cancer and quantitatively assessed the factors correlated with the gender-based difference in mortality. In comparison with female patients, across all stages, higher mortality was noted in male patients. Overall, for male patients, clinical features and undertreatments were correlated with a 63.3% excess mortality rate. In the first 3 years following a breast cancer diagnosis and in all patients with early-stage cancer, a greater proportion of excess deaths in men were defined by these factors. Nevertheless, gender continued to be a notable factor related to overall mortality as well as mortality at 3-year and 5-year analyses, even subsequent to adjustment for clinical features, treatment factors, age, race/ethnicity, and access to care. In conclusion, this study observed that mortality following cancer diagnosis was higher among male patients with breast cancer in comparison with their female equivalents. Such difference seemed to continue subsequent to accounting for clinical features, treatment factors, and access to care, implying that other factors (especially additional biological attributes, treatment compliance, and lifestyle factors) should be recognized to aid in eradicating this incongruity.