Ramonell KM, Fazendin J, Lovell K, et al. - The adult population can safely undergo parathyroidectomy for primary hyperparathyroidism (pHPT) in the outpatient setting. However, in the pediatric population, limitations in same-day discharges have been faced because of the concern that children and adolescents have higher complication rates and are unable to identify and communicate symptoms of hypocalcemia. Researchers here reviewed patient demographics, disease, operations, and complications in 19 patients aged 8-18 years (14.1±0.7) who underwent outpatient parathyroidectomy for pHPT by a single high-volume endocrine surgeon from 2002-2020. Symptoms were present in 16 of 19 patients with fatigue (62.5%), joint pain (37.5%) and nephrolithiasis (18.7%) most common. Eleven four-gland explorations, 8 unilateral parathyroidectomies were conducted among these patients; including 9 transcervical thymectomies, 1 total thyroidectomy, and 1 bilateral central neck dissection. Outcomes revealed occurrence of no temporary or permanent hoarseness, unplanned same-day admission, wound complications, or emergency department visits. They overall indicate safety and effectiveness of performing outpatient parathyroidectomy in pediatric patients with primary HPT.