Iglicki M, et al. - In patients with naïve diabetic macular oedema (DMO) seen after small gauge pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling, researchers conducted this retrospective cohort study to examine a novel optical coherence tomography (OCT) finding of outer retinal hyperreflective deposits (ORYDs). In addition, the predictive value of ORYD for visual outcome over 24 months follow-up was assessed. This investigation involved 111 eyes from 111 individuals (mean age 67.5 ± 14.8 years) with naïve DMO treated by PPV and ILM peeling with a follow-up of 24 months. The presence of ORYD 1 week and 1, 6, 12, 18 and 24 months after surgery was analyzed for OCT scans. They described a novel OCT feature of ORYD present in most patients after PPV with ILM peeling for naïve DMO in the early postoperative phase, disappearing during the postoperative course. These deposits could lead from sudden desinflammation and after surgical intervention could shed new light on the DMO resolution process.