Egbe AC, et al. - In this retrospective cohort study, researchers compared patients with and without hemodynamically significant right ventricle outflow tract (RVOT) for the incidence of pregnancy-related adverse outcomes (PRAO). Participants were all pregnant patients having isolated RVOT lesions undergoing an assessment at the Mayo Clinic, 1990 to 2017. Cardiovascular, obstetric, and/or neonatal complications happening during the pregnancy through 6 weeks postpartum defined PRAO. Overall 114 patients with RVOT lesions with 224 pregnancies were included, with 38 pregnancies in 24 patients with hemodynamically significant RVOT. According to the findings, patients with isolated RVOT lesions had a low risk of cardiovascular complications. No association with either cardiovascular complications or PRAO was shown by hemodynamically significant RVOT lesions. Spontaneous abortion and neonatal complications were reported in relation to Tetralogy of Fallot–pulmonary atresia, as an isolated entity.