Starr MR, Mahr MA, Smith WM, et al. - Researchers conducted this retrospective clinical cohort study to examine the outcomes of cataract surgery in patients with active diabetic macular edema (DME) who are receiving active treatment with intravitreal anti-vascular endothelial growth factor (VEGF) injections in the perioperative period. From January 1, 2012, to December 31, 2017, all patients who underwent cataract surgery and received intravitreal anti-VEGF injections were included. When comparing all eyes, there was a significant improvement in pre-and post-operative BCVA but no significant difference in CST before and after surgery. In a real-world setting, patients with cataracts and actively treated DME may undergo cataract surgery, but the DME may worsen without immediately affecting the BCVA.