Sarraj A, Hassan AE, Savitz S, et al. - In this prespecified secondary analysis of a cohort study, researchers assessed results in patients with large ischemic cores treated with endovascular thrombectomy (EVT) and medical management vs medical management alone. Patients were eligible if they had moderate to severe stroke and large-vessel anterior circulation occlusion up to 24 hours from the moment they were last known to be well. The study sample consisted of 105 patients with large ischemic cores on either computed tomography (CT) or CT perfusion images. According to findings, EVT can be beneficial for patients with large infarcts, particularly if they are treated early and if they have a core volume of less than 100 cm3. While a clear decline in odds of good outcomes is seen as core size and time for treatment increases in patients with large cores receiving EVT, potential benefits are still possible. In 31% of patients who received endovascular thrombectomy vs 14% who received medical management only, functional independence was reached; in both groups, deaths, neurological worsening, and symptomatic intracerebral hemorrhage were seen in comparable proportions. The likelihood of functional independence was reduced by 40% with each hour delay and 42% with each 10-cm3 increase in stroke volume.