Kantamalee W, et al. - A cohort of 151 pediatric patients with first-episode community-onset urinary tract infection (UTI) caused by Escherichia coli, Klebsiella pneumoniae and Proteus spp. at Ramathibodi Hospital was retrospectively analyzed in order to determine if inappropriate empirical therapy (IAT) of community-onset UTI results in adverse clinical outcomes. Classification of the patients into IAT and appropriate empirical therapy (AT) groups was done. E. coli was identified to be the most common causative organism (88.8% and 96.2% in the AT and IAT groups, respectively). Consequences revealed no significant difference in treatment outcomes between pediatric patients receiving AT and IAT for the treatment of UTI. Researchers identified third-generation cephalosporins as a good choice as an empirical antimicrobial for children diagnosed with community-onset UTI in this era of increasing antimicrobial resistance.