Clayton JA, et al. - Researchers analyzed the Virtual Pediatric Systems database, to compare the rate of subsequent invasive mechanical ventilation following initial support with noninvasive positive pressure ventilation or high-flow nasal cannula in children with bronchiolitis. This study was performed in 92 participating PICUs and included children less than 2 years old admitted to a participating PICU between 2009 and 2015. The participants were treated with high-flow nasal cannula or noninvasive positive pressure ventilation initially. A total of 6,496 subjects with a median age 3.9 months (1.7–9.5 mo), with male predominance (59.7%), and 23.4% with an identified comorbidity were included. Findings revealed that higher rates of invasive mechanical ventilation were observed in relation to the use of noninvasive positive pressure ventilation, even after adjusting for demographics, comorbid condition, and severity of illness.