Nolan HR, Wagner ML, Jenkins T, et al. - Large abdominal wall defects, physiologic aberrancies, and congenital anomalies complicate morbidity and mortality in the giant omphalocele population, researchers here examined if different anomalies and treatment types affect outcomes. Performing a 2009–2018 retrospective chart review of giant omphaloceles, they included 35 patients and categorized them based on mortality and operative morbidity into favorable (n = 20) or unfavorable (n = 15) outcomes. Analysis of multiple variables was required for predictions of overall outcomes in the giant omphalocele population. Per findings, odds of unfavorable outcomes were higher in correlation with major cardiac anomalies, pulmonary hypertension, genetic diagnosis, other major anomalies, polyhydramnios, postnatal sac rupture, increasing omphalocele sac diameter, lower O/E TLV, lower gestational age at birth, lower birth weight, and repair other than primary. In those surviving to repair, patients able to be closed primarily had an earlier age of repair and a shorter length of stay in surgical outcomes analyses.