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Outcomes in Kawasaki disease patients with coronary artery abnormalities at admission

American Heart Journal May 07, 2020

Ae R, Abrams JY, Maddox RA, et al. - Given that Kawasaki disease (KD)-induced coronary artery lesions (CALs) can improve over time has been shown in previous studies but there exists limited information about sub-acute outcomes of CALs identified at admission during KD illness, so to inquire this, researchers analyzed KD patients with CALs identified at admission and who were managed with standard IVIG treatment within 10 days of disease onset, via a nationwide Japanese KD survey. There were overall 2,024 patients with CALs identified at admission, among those, improved, unchanged, and progressed results were evident in 1,548 (76.5%), 390 (19.3%), and 86 (4.2%), respectively. Improved outcome was observed in over 80% of patients having coronary artery dilatations. It was concluded that more rigorous treatment may be needed for KD patients with larger CALs, ≥ 60 months old, and with recurrent status or parental history. Additionally, worse coronary outcome may be seen in relation to delayed admission, this suggests a need for prompt diagnosis and treatment.

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