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Outcome of fetuses with prenatal diagnosis of isolated severe bilateral ventriculomegaly: Systematic review and meta-analysis

Ultrasound in Obstetrics & Gynecology Aug 17, 2018

Carta S, et al. - Researchers aimed at quantifying survival and neurodevelopmental outcome of fetuses with prenatally detected isolated severe bilateral ventriculomegaly via analyzing published literature from MEDLINE, EMBASE and the Cochrane Library. They identified 11 studies including 137 fetuses. Findings suggest that four-fifths of these fetuses survive. Normal neurodevelopment was observed in just over two-fifths of the survived fetuses. The overall survivors without disability account for more than one-third of the total. Higher mortality and prevalence of developmental delay than that reported in this paper is expected as many cases undergo termination of pregnancy and require longer follow-up in order to detect subtle abnormalities.
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