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Osteoarthritis development related to cartilage quality- The prognostic value of dGEMRIC after anterior cruciate ligament injury

Osteoarthritis and Cartilage Jul 10, 2019

Jon Tjörnstrand, et al. - Through a prospective cohort study of 31 patients with anterior cruciate ligament (elevates the risk of developing osteoarthritis {OA}) injury, the researchers intended to examine the prognostic value of the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) index about future knee OA. Radiographic OA (ROA) was observed in 68% and OA symptoms (SOA) in 42% of the injured knees, at the 14-year follow up. In comparison to those that did not develop ROA, SOA or poor function, lower dGEMRIC index of the medial compartment in knees that developed medial ROA and poor knee function was observed. A negative association of the dGEMRIC index with the OARSI osteophyte score in media and lateral compartments was discovered. Hence, the correlation between a low dGEMRIC index and future ROA, as well as SOA was found having an agreement with prior studies and it symbolized a prognostic value of dGEMRIC for future knee OA.
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