Etminan M, et al. - In view of an increase in fluoroquinolone (FQ) prescription rates over the last 10 years despite recent warnings of serious adverse effects such as peripheral neuropathy and tendinopathy, researchers sought to determine the extent or appropriateness of FQ prescribing in children. From the PharMetrics Plus health claims database (United States), they analyzed drug prescription data to examine dispensing of ciprofloxacin, levofloxacin, moxifloxacin, ofloxacin, or gemifloxacin to children from 2006 to 2015. As per observations, the increase FQs prescribing mostly included ciprofloxacin over a 10-year period, although there appeared a slight decrease in the number in 2014 and 2015. They identified at least 1 in 5 prescriptions as unnecessary. Clinicians are advised to avoid using FQs for uncomplicated community-acquired infections considering the recent FQ safety warnings and lack of long-term safety data with FQ use in children and potential risk of increasing antibiotic resistance.