Michels KA, et al. - The association of oral contraceptives (OC) use with the risk of development of incident cancers, was explored in women in the prospective NIH-AARP Diet and Health Study (enrolled 1995–1996, followed until 2011). Findings demonstrated that any OC use conferred a 3% reduction in the risk for any cancer. Notably, expected risk reductions that strengthened with duration of use were identified for ovarian and endometrial cancers and were suggested for kidney cancer. Moreover, 10+ years of use reduced risk for non-Hodgkin lymphoma. Among long-term users who were ≤60 at baseline, 37% reduced risk for bladder cancer and 46% increased risk for pancreatic cancer was noted. Notably, OC use did not impact risks for most other cancers evaluated. The reported prevalence of use was high.