Duval S, Pepe PE, Aufderheide TP, et al. - Considering the findings from previous studies of basic cardiopulmonary resuscitation (CPR) suggesting the correlation of both chest compression rate (CCR) and chest compression depth (CCD) with survival probability after out-of-hospital cardiac arrest, researchers sought to identify an optimal CCR-CCD combination, particularly with respect to age, sex, presenting cardiac rhythm, and CPR adjunct use, in this cohort study of data from 3,643 individuals in the National Institutes of Health clinical trials network database. As per findings, they noted significantly improved outcomes for out-of-hospital cardiac arrest in correlation with the combination of 107 compressions per minute and a depth of 4.7 cm. Regardless of age, sex, presenting cardiac rhythm, or cardiopulmonary resuscitation adjunct use, the finding remained relatively consistent. They noted significant improvements in outcome in correlation with adjunct use but delivering the identified optimal chest compression rate and depth combination influenced this finding.