Grego L, Pignatto S, Alfier F, et al. - This study was intended to ascertain the presence of sickle cell retinopathy and maculopathy and to distinguish correlations between markers of hemolysis and systemic and ocular manifestations in children influenced by sickle cell disease. Researchers included a total of 18 children with sickle cell disease, aged 5–16 years, who had undergone complete eye examination including best-corrected visual acuity, slit-lamp biomicroscopy, ophthalmoscopy after pharmacological mydriasis, spectral-domain optical coherence tomography (SD-OCT), and optical coherence tomography angiography (OCTA). They collected blood test results and clinical history information for each child, including fetal hemoglobin, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, reticulocytes percentage, lactic dehydrogenase, total and direct bilirubin, glomerular filtration rate, number of painful crises, acute chest syndromes, and splenic sequestration. Early signs of sickle cell retinopathy and maculopathy were noted in a pediatric population with SD-OCT and OCTA. It was shown that in children with higher hemolytic rates, these two retinal complications were more frequent.