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Optic nerve sheath diameter ultrasound: Optic nerve growth curve and its application to detect intracranial hypertension in children

American Journal of Ophthalmology Aug 07, 2019

Liviana F, et al. - In this prospective cross-sectional study, researchers developed an optic nerve growth curve from the optic nerve sheath diameter (ONSD) normal values ​​measured with B-scan ultrasound in individuals 0-18 years of age and identified age-appropriate ONSD cut-offs for intracranial hypertension (IHT) diagnosis. They performed B-scan ocular ultrasound on both eyes of 215 individuals aged 0-18 and divided into three groups: 165 healthy children, 29 children with IHT (all > 4 years of age) and 21 with optic disc drusen (ODD). Between healthy children and individuals with ODD, no statistically significant differences were found in ONSDs. Using ONSDs measured in healthy individuals aged 0-18: ONSD = ln (33.15) – [–0.18 * ln (children’s age)], an optic nerve growth curve was created. Until the age of 10, the ONSD continues to enlarge gradually. For the age groups 4-10 and 11-18, therefore, the authors calculated two different cut-offs, considering the ONSDs of individuals aged 11-18 overlapping with those of adults. Since there were no patients with IHT < 4 years, further studies are required to assess the correct cut-offs for these ages.
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