Marmor M, et al. - In view of the observation that many individuals with cystic fibrosis (CF), who survive into adulthood, have multi-faceted symptoms that impair their quality of life, researchers sought for opportunities to improve utilization of palliative care among these adults via performing a systematic review. Searching PubMed, Embase, Scopus, Web of Science and CINAHL databases, they identified 12 eligible studies for inclusion in this work. As per findings, while 43% to 65% of adults with CF had contemplated completing advanced care planning (ACP), ACP was completed by the majority only during their terminal hospital admission. They identified reports of a high prevalence of untreated symptoms among these adults with adequate symptom control in 45% among those with dyspnea, 22% among those with pain and 51% among those with anxiety and/or depression. In-hospital death ranged from 62% to 100%, with the death of a third in the ICU. Antibiotics and preventative treatments were provided to the majority of the patients during their terminal hospitalization. Finally, they observed a higher prevalence of patient completion of advanced directives, decreased likelihood of in-ICU death and decreased use of mechanical ventilation at end-of-life in correlation to the treatment from a palliative care specialist. These findings suggest the existence of many opportunities for palliative care specialists to promote ACP completion and quality of end-of-life care.