Zhang V, et al. – Since 1999, deaths due to overdose involving prescription opioids have increased five-fold in the United States, with benzodiazepines frequently involved in opioid-related overdoses. Concomitant use of benzodiazepines and opioids has been shown to elevate the risk of overdose and death. In light of the increasing rate of co-prescriptions, the FDA issued a boxed warning on August 31, 2016, emphasizing the risks of co-prescribing opioids and benzodiazepines. Previous investigators evaluated trends before the warning, and found a reduction in opioid prescribing after the March 2016 CDC guideline. However, it remains to be elucidated whether co-prescriptions have further significantly declined following the boxed warning. Therefore, researchers for the first time reported on the national estimate of opioid and benzodiazepine co-prescribing before and after the boxed warning in this study.