Sapantzoglou I, Wright A, Gallardo Arozena M, et al. - Researchers conducted this prospective observational study to investigate the potential value of maternal ophthalmic artery Doppler at 19–23 weeks' gestation on its own and in combination with the established biomarkers of pre‐eclampsia (PE), including uterine artery (UtA) pulsatility index (PI), mean arterial pressure (MAP), serum placental growth factor (PlGF) and serum soluble fms‐like tyrosine kinase‐1 (sFlt‐1), in the prediction of subsequent development of PE. The sample consisted of women attending for a routine hospital visit at 19 + 1 to 23 + 3 week of gestation. The study population of 2853 pregnancies included 76 (2.7%) that developed PE, including 18 (0.6%) that delivered with PE at < 37 weeks of gestation. The PSV ratio strengthened the preterm PE forecast by maternal factors alone, maternal factors, MAP and UtA‐PI, maternal factors, MAP, UtA‐PI and PlGF and maternal factors, MAP, UtA‐PI, PlGF and sFlt‐1, at a FPR of 10%. Ophthalmic artery PSV ratio at 19–23 weeks of gestation, both on its own and in combination with other biomarkers, is potentially useful for predicting the subsequent development of PE, particularly preterm PE, but larger studies are required to confirm this finding.