Incalzi RA, Blasi F, Scichilone N, et al. - This study was carried out to present the 1-year evolution of symptoms and health status in chronic obstructive pulmonary disease (COPD) patients enrolled in the STORICO study (observational study on characterization of 24-h symptoms in patients with COPD) classified in multidimensional phenotypes (m-phenotypes). An exploratory factor analysis was conducted to distinguish clinical and pathophysiological variables having the greatest classificatory properties, followed by cluster analysis to group patients into m-phenotypes (mild COPD (MC), mild emphysematous (ME), severe bronchitic (SB), severe emphysematous (SE), and severe mixed COPD (SMC)). Researchers recorded COPD symptoms at baseline, 6-, and 12-month follow-up and their evolution was described as the frequency of patients with always present, always absent, arising’, ‘no more present symptoms. The SGRQ and CASIS questionnaires were used to evaluate QoL and quality of sleep respectively. For the analysis, 379 individuals were examined (144 MC, 71 ME, 96 SB, 14 SE, 54 SMC). As per the findings, severe m-phenotypes exhibited an improvement in night-time symptoms and quality of sleep, but not QoL over one year. The data exhibited that, being stable over time, m-phenotypes appear worthy of testing for classificatory and prognostic purposes.