Margenthaler JA, Gan C, Yan Y, et al. - Researchers sought to report their experience with nipple-sparing mastectomy (NSM), which is identified as an alternative to skin-sparing mastectomy in appropriately selected patients. Further, they evaluated it for oncologic safety. From September 2008 through August 2017, they identified 322 patients who underwent 588 NSM (83% bilateral, 17% unilateral), including 399 (68%) for malignancy [Stage 0 (27%), I (44%), II (25%) and III (4%)]. The overall rate of wound complications of 18.9% was reported. Tobacco use and adjuvant radiation therapy were identified to be associated with increased complication rates. Higher rates of complications were reported among patients with lymph node involvement and larger tumor size (31.3% vs 17.2%). Patients undergoing circumareolar incisions, vs those undergoing lateral radial, inframammary fold, or curvilinear incisions, had a higher rate of complications. These findings suggest that in patients with malignancy, researchers most frequently performed NSM. The low locoregional recurrence rate establishes the oncologic safety of the procedure.