Hyman JB, Park C, Lin HM, et al. - Researchers conducted this prospective, randomized, double-blind, parallel-group, placebo-controlled study in order to test the hypothesis that oral olanzapine is superior to placebo at preventing postdischarge nausea and vomiting. A single preoperative dose of olanzapine 10 mg was compared with placebo in adult female patients 50 years old or less, undergoing ambulatory gynecologic or plastic surgery with general anesthesia. All the 140 randomized patients were administered standard antiemetic prophylaxis with dexamethasone and ondansetron. As per outcomes, the risk of nausea and/or vomiting in the 24 h after discharge from ambulatory surgery reduces by about 60% with a slight increase in reported sedation when olanzapine, vs placebo, is provided with ondansetron and dexamethasone.