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Odor selectivity of hyposmia and cognitive impairment in patients with Parkinson’s disease

Clinical Interventions in Aging Oct 18, 2017

Mao CJ, et al. - Authors aimed to identify bromines that could effectively determine the olfactory dysfunction. They also examined the relationship between hyposmia and cognitive function in early, non-demented, drug-naïve patients with Parkinson’s disease (PD) in the People’s Republic of China. In early, non-demented, drug-naïve PD patients, hyposmia was common. For identifying hyposmia, β-Phenylethyl alcohol and isovaleric acid were more superior in early non-demented Chinese patients with PD. Among patients with PD, hyposmia was correlated with impaired visuospatial and executive function. Further prospective studies that applied a series of neuropsychological tests and functional magnetic resonance imaging methods in large samples in multicenter studies were required to confirm the findings and to examine the relationship between hyposmia and cognitive function with disease progression in patients with PD.
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