Ocular complications in school-age children and adolescents after allogeneic bone marrow transplantation
American Journal of Ophthalmology Feb 04, 2020
Hoehn ME, Vestal R, Calderwood J, et al. - Researchers conducted this retrospective cohort study to ascertain the ocular complications in school-age children and adolescents surviving at least one year after allogeneic bone marrow transplantation. One hundred sixty-two (7-18 years old) patients met the inclusion criteria with a mean age of 13.4 years at bone marrow transplantation. The development of cataracts was reported in 57 patients. Univariate analysis exhibited that age at transplantation, steroid use, chronic graft-versus-host disease, fludarabine use, melphalan use, thiotepa use, and receiving no pretransplant conditioning regimen prior to bone marrow transplant significantly raised the dry eye syndrome risk. Chronic graft-versus-host disease was a significant risk factor for dry eye syndrome in multivariate analysis. Because of the high incidence of cataract formation and dry eye disease in this population, the authors recommend screening tests at least annually by a pediatric or general ophthalmologist.
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