Cunha JP, et al. – The peripapillary retinal nerve fiber layer (pRNFL) thickness and overall retinal thickness (RT) in Alzheimer's disease (AD) patients with non–AD patients underwent a comparative assessment, via spectral domain optical coherence tomography (SD–OCT). The sectors most characteristically affected in AD were also determined during this study. The AD patients illustrated a marked thickness reduction in global and temporal superior quadrants in pRNFL and in superior pericentral and peripheral sectors of RT. This data possibly reflected peripapillary and retinal variations which were characteristic of AD. This, in turn, indicated the significance of SD–OCT as a potential adjuvant in the initial diagnosis of AD. An advanced research was warranted to comprehend which retinal layers and macular sectors were more beneficial as potential ocular biomarker over time in AD.