Miguel A, Silva A, Barbosa-Breda J, et al. - Given that optical coherence tomography angiography (OCTA) allows the study of vessel density (VD), researchers sought to concentrate on longitudinal changes in peripapillary and macular VD measurements in glaucoma. Ten out of 4,516 studies were involved in this systematic review. Findings revealed that the rate of VD change in glaucoma ranged from 0.036/year to 1.08/year and 1.3% to 3.2% per year, with significantly different rates between glaucoma and healthy controls. OCTA is a non-invasive technology that is promising in glaucoma. Measures should be taken to improve quality and standardize the VD measurement methodology for future meta-analyses in OCTA longitudinal studies.