Szabo YT, Baky FJ, McKenzie TJ, et al. - Given that Cowden syndrome patients are at an increased risk of developing differentiated thyroid carcinoma (DTC), researchers characterized the frequency and progression of DTC in this population. All patients with clinically or genetically confirmed Cowden syndrome treated at the institution between 1979 and 2017 were reviewed. Forty-seven patients have been identified. Findings revealed that patients with Cowden syndrome are at a significantly higher risk of developing DTC and have a younger age of onset. Data reported that 20% of the patients with Cowden syndrome were diagnosed with DTC, but there was no distant metastasis and overall mortality. Clinical characteristics were comparable to those of sporadic DTC, which shows that, apart from screening, Cowden syndrome-related DTC can be treated in similar fashion.