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Occupational exposure to inhaled pollutants and risk of airflow obstruction: A large UK population-based UK Biobank cohort

Thorax May 13, 2020

Sadhra SS, Mohammed N, Kurmi OP, et al. - By performing this cross-sectional study among 228,614 participants, researchers evaluated the effect size of the link between several airborne occupational pollutants (AOP), their level as well as duration of exposure with airflow obstruction (AFO). These participants were selected from the UK Biobank study and were assigned occupational exposure using a job exposure matrix blinded to health outcome. Robust Poisson model was employed to estimate adjusted prevalence ratios as well as 95% CI for the risk of AFO for ever and years of exposure to AOPs. A rise in the risk of occupational AFO by 26% was noted in relation to high exposure to vapours. A significantly raised risk of AFO was demonstrated by exposure to dusts, biological dusts and VGDF (vapours, gases, dusts or fumes), however, statistically not significant after multiple testing. Overall, a higher risk of AFO was suggested by high exposure (in current job) to airborne occupational pollutants.

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