Obstructive sleep apnea and non-alcoholic fatty liver disease in obese patients undergoing bariatric surgery
Obesity Surgery Mar 08, 2020
Schwenger KJP, Ghorbani Y, Li C, et al. - Given an association of morbid obesity with multiple comorbidities including obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD), researchers here examined the apnea-hypopnea index (AHI) and lower minimum oxygen saturation, markers of OSA, in cases undergoing bariatric surgery (BSx) with perioperative liver biopsy to detect NAFLD. In this single-center cross-sectional study, 61 patients undergoing BSx underwent biochemical, clinical, anthropometric variables, and a sleep study test prior to BSx. Among these, 49 (80.3%) patients were diagnosed with NAFLD and 12 had normal liver (NL). Outcomes revealed higher AHI and lower minimum oxygen saturation among cases with NAFLD vs NL. They identified a correlation of AHI with liver inflammation inferring a possible role for intermittent nocturnal hypoxia in the pathogenesis and progression of NAFLD.
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