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Obesity is not associated with progression to end stage renal disease in patients with biopsy-proven glomerular diseases

BMC Nephrology Jul 09, 2019

Elyan BMP, et al. - Researchers investigated patients with biopsy-proven primary glomerular disease (GN) (excluding minimal change disease) in this single-centre retrospective cohort study to determine the link between body mass index (BMI) and renal disease progression in these patients. The patients had follow-up data available until June 2017. Of 560 patients included, 66.1% were male with median age 54.8 years and BMI 28.2 kg/m2. Patients with higher BMI had a greater proportion of focal segmental glomerulosclerosis (3.9% in BMI < 25 kg/m2, 7.9% in BMI 25–30 kg/m2 and 10.7% in BMI > 30 kg/m2 of biopsies), but different BMI groups had similar proportions of other GN diagnoses. Younger age, lower baseline estimated glomerular filtration rate and higher urinary protein to creatinine ratio were found to be related to progression to MARE (major adverse renal event), censoring for competing risk of death. In this patient cohort with primary GN, findings revealed no link between BMI and progression to MARE. Directing efforts at managing other recognized risk factors for chronic kidney disease progression is recommended.
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