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Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive‐aged women with polycystic ovary syndrome: A systematic review and meta‐analysis of 45 observational studies

Obesity Reviews Apr 19, 2021

Kazemi M, Pierson RA, Parry SA, et al. - Researchers conducted a systematic review and meta‐analysis examining if polycystic ovary syndrome (PCOS) alters muscle mass and function. From databases (MEDLINE, Web of Science, Scopus), they retrieved 45 eligible studies (n = 3,676 participants). Increased total yet comparable trunk lean body mass (LBM) or fat‐free mass (FFM) were recorded in women with PCOS vs controls. Meta‐regression analyses suggested no correlations between mean differences between groups in total testosterone or homeostatic model assessment of insulin resistance and total or trunk LBM or FFM. Greater total LBM or FFM were recorded for the PCOS subgroup with BMI ≥ 25 kg/m2 vs controls unlike the PCOS subgroup with BMI < 25 kg/m2. Appendicular lean mass and muscle strength data were contradictory and described narratively, as meta‐analyses were impossible. Overweight/obesity was linked with higher total and trunk lean tissue mass among cases with PCOS, unlike hyperandrogenism or insulin resistance.

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