Cobb LP, Siamakpour-Reihani S, Zhang D, et al. - In endometrial cancer (EC), tumor progression may be seen in presence of obesity as it results in differential modulation of angiogenic pathways. EDIL3 is suggested to be a candidate gene of interest.

• The correlation between 168 human angiogenic-related genes and body mass index (BMI) was examined in the TCGA Uterine Corpus Endometrial Carcinoma cohort (endometrioid endometrial cancer (EEC) cohort n = 290, and copy number high cohort n = 55), an independent validation cohort from Gynecologic Cancer Center of Excellence (GYN-COE) (n = 62) and corresponding 185 homologous mouse genes in an LKB1^fl/flp53^fl/fl mouse model of EC (n = 20).

• At a false-discovery rate of 10%, researchers identified differential expression of 21 angiogenic-related genes with respect to BMI.

• In the mouse model control group, mice receiving high-fat diet (HFD) showed increased Edil3 expression relative to mice receiving low-fat diet (LFD) (2.5-fold change (FC)).

• For expression of Edil3, there appeared an interaction between diet and metformin treatment.