Yu G, Zhang Y, Meng B, et al. - Researchers sought to determine the IgA1 O-glycoforms in the hinge region (HR) of polymeric IgA1 and assessed the connection between IgA1 O-glycoforms and crescent formation in IgA nephropathy (IgAN). This analysis involved a discovery cohort (cohort 1), consisting of 11 crescentic IgAN patients, 10 noncrescentic IgAN patients and 10 healthy controls, as well as a validation cohort (cohort 2) including 11 crescentic IgAN patients, 9 noncrescentic IgAN patients, and 9 healthy controls. Also, a cohort 3 was included which consisted of 143 IgAN patients with different crescent percentages. Evaluation of variation in O-glycoforms was done. Per findings, the numbers of GalNAc in IgA1 HRs were shown to be lower in IgAN cases, particularly in crescentic IgAN patients, and may be related to a severe IgAN phenotype.