Huang ZY, Huang Q, Wang LY, et al. - A prospective cross-sectional study was designed to acknowledge the normal trajectories of interleukin-6 (IL-6) and C-reactive protein (CRP) in the immediate hours and days after primary total knee arthroplasty (TKA) under the management of an enhanced recovery after surgery (ERAS) protocol and examined whether one or the other returned to normal more quickly. The plasma IL-6 and CRP levels were analyzed in 100 patients undergoing primary TKA at the following time points: 12 h preoperatively as well as postoperatively 12 h, 48 h, 3 days and 2 weeks. The follow up period of the patients was one year to monitor the postoperative complications, especially the infection. Study observed that compared with previous studies, under the ERAS scenario, the postoperative peak of IL-6 and CRP was deferred. CRP revealed a gradual rise after surgery compared with IL-6. Both of these two biomarkers returned to normal under the ERAS scenario. Future multiple-center studies with larger sample size are needed to characterize the thresholds of IL-6 and CRP for periprosthetic joint infection (PJI) early diagnosis. A clinician can make a quicker decision to conduct aspiration to predict early PJI and benefits more patients.