Ou WC, Lesmes LA, Christie AH, et al. - Researchers conducted this cross-sectional study to evaluate the effectiveness of an active learning approach to measuring the contrast sensitivity function (CSF) in patients with various degrees of dry age-related macular degeneration (AMD) under multiple luminance conditions. The Manifold Contrast Vision Meter (Adaptive Sensory Technology, San Diego, CA) and the qCSF algorithm were evaluated in patients with AMD (26 intermediate AMD, 19 AMD with subretinal drusenoid deposits (SDD), 20 geographic atrophy (GA)) and 23 age-matched controls, using active learning to estimate the CSF's global shape model. Progressive decreases in the area under log CSF were noted as disease severity increased. Contrast sensitivity measured by qCSF under both standard and low luminance conditions is correlated with advancing stages of dry AMD. The interaction between luminance and contrast sensitivity seems to reflect a different aspect of visual function than the interaction between luminance and VA.