Barrera CA, Andronikou S, Tapia IE, et al. - This study was sought to define the normal progression of quantitative CT parameters in normal children from birth to adulthood. Researchers included patients aged 0–18 years with non-contrast-enhanced chest CT and evidence of normal lung parenchyma. They excluded patients with respiratory symptoms, incomplete anthropometric measurements, or sub-optimal imaging techniques. They conducted segmentation by applying open-source software with an automated threshold segmentation. The study included a total of 220 patients (111 females, 109 males), mean age was 9.6 ± 5.9 years, and mean height was 133.9 ± 35.1 cm. This study’s findings demonstrate that the quantitative CT parameters of the lung parenchyma demonstrate variations from birth to adulthood. According to the findings, as children grow, the mean lung density reduces, and the lung parenchyma becomes more homogenous.