Hurley ET, et al. - Via performing this systematic review of randomized controlled trials, researchers appraised the utility of platelet-rich plasma (PRP) for nonoperative treatment of rotator cuff disease. The inclusion criteria were met by 5 randomized controlled trials including with 108 patients treated with PRP and 106 treated with a control. As per the limited available evidence, no possible benefit of PRP injections in the short term was evident. No superior functional outcomes, pain scores, or range of motion were achieved with PRP when directly compared with exercise therapy.