Loss M, Thompson KG, Agostinho‐Hunt A, et al. - In the present study, the researchers sought to investigate biofilm and skin microbiota in acne patients in order to understand their role in the development of acne lesions. Thin sections of punch biopsy specimens of uninflamed comedones, inflammatory lesions, and uninvolved adjacent skin of acne patients have been examined. Of the 39 skin specimens of patients with mild‐moderate acne (n = 13) examined, nine (23%) contained biofilm. Among such specimens, biofilm was most frequently found in comedones and less frequently in inflammatory papules and uninvolved skin. Compared with uninvolved skin, the relative abundance of Staphylococcus in comedones was significantly greater. Comedone's microenvironment varies from that of inflammatory lesions and skin that is not affected. Increased biofilm frequency in comedones can be associated with a lack of host inflammatory response to these lesions.