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Noncancer mortality among adolescents and young adults with cancer

Cancer Mar 27, 2019

Anderson C, et al. - Researchers used the SEER database to determine the rates of noncancer mortality among adolescent and young adult (AYA; aged 15-39 years) patients who received a diagnosis of a first malignant cancer between 1973 and 2015, and compared these rates with those observed in the general US population via standardized mortality ratios (SMRs) that were adjusted for age, sex, race, and calendar year. An increased burden of mortality from noncancer causes was observed among AYAs with cancer, which continued to persist over many years post-cancer diagnosis. This was suggestive of the significance of providing comprehensive, long-term follow-up care for noncancer conditions during survivorship. Especially for infectious diseases, cardiovascular disease, and renal diseases, raised SMRs were reported. Leukemias, Hodgkin lymphoma, non-Hodgkin lymphoma, central nervous system tumors, head and neck cancers, and cervical/uterine cancers were found to be linked to the highest SMRs for all noncancer mortality.

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