Park H, et al. - Via a retrospective cohort analysis of the Truven Health MarketScan Database (2006–2015) (n = 262,619), experts ascertained the longitudinal correlation of nonalcoholic fatty liver disease (NAFLD) with the development of advanced chronic kidney disease (CKD) in the United States. In the multivariable Cox model, patients with NAFLD vs non-NAFLD patients had a 41% progressed risk of developing advanced CKD. In the sensitivity analysis adjusting for time-varying covariates following NAFLD diagnosis, NAFLD continued as an important CKD risk factor and the correlation prevailed to be important when stratified by age, gender, and preexisting comorbidities. In NAFLD with compensated cirrhosis and decompensated cirrhosis, the risk of CKD rose. Therefore, NAFLD was independently related to a progressed risk of advanced CKD development recommending renal function screening and regular monitoring are required in this population.