Sinn DH, Kang D, Chang Y, et al. - Researchers examined how non-alcoholic fatty liver disease (NAFLD) is associated with the risk of incident myocardial infarction via retrospectively studying a cohort of 111,492 adults over 40 years old without history of cardiovascular disease, liver disease, or cancer at baseline. Myocardial infarction developed in 183 participants during 725,706.9 person-years of follow-up (incidence rate 0.3 cases per 1,000 person-years). Relative to participants without NAFLD, participants with low NAFLD fibrosis score (NFS) (< −1.455) and with intermediate-to-high NFS (≥ −1.455) exhibited the fully adjusted HRs for incident myocardial infarction of 1.70 (1.22, 2.36) and 1.88 (1.24, 2.87), respectively. Findings thereby demonstrate the correlation between NAFLD and an increased incidence of myocardial infarction; this association was evident independent of established risk factors. Further, this correlation was similar in participants with and without evidence of more advanced NAFLD as indicated by the NFS. This emphasizes the necessity for careful monitoring of NAFLD patients and managing them early to prevent myocardial infarction.