Chang JC, Xiao R, Meyers KE, et al. - This study was carried out to ascertain if non-dipping is a useful marker of abnormal vascular function and subclinical atherosclerosis in pediatric-onset systemic lupus erythematosus (pSLE). Researchers included a total of 20 individuals 9–19 years of age with pSLE who had undergone ambulatory blood pressure monitoring (ABPM), peripheral endothelial function testing, carotid-femoral pulse wave velocity/analysis for aortic stiffness, and carotid intima-media thickness. They evaluated the prevalence of non-dipping and other ABPM abnormalities. Applying Pearson or Spearman rank correlation tests, relationships between nocturnal BP dipping, BP load (% of abnormally elevated BPs over 24-h), and vascular outcome measures were measured. This study's findings demonstrate that isolated nocturnal BP non-dipping is prevalent and correlated with endothelial dysfunction and atherosclerotic changes in a pSLE cohort with low disease activity. It was considered that ABPM has a promising role in risk stratification and understanding heterogeneous mechanisms of cardiovascular disease in pSLE, in addition to hypertension assessment.