Pisa M, et al. - This longitudinal study was performed to investigate the usefulness of optical coherence tomography (OCT) in monitoring people with multiple sclerosis (MS) by testing the association between retinal nerve fiber layer (RNFL) thinning and clinical and brain MRI criteria of no evidence of disease activity (NEDA). The authors revealed that NEDA was correlated with a relatively preserved RNFL over 2 years. They detected a greater neuroretinal loss even in patients with clinical evidence of disease activity independently from changes in brain MRI lesions, indicating further validation of OCT as an additional tool in MS monitoring.