Thompson M, et al. - In a multigenerational cohort of the Tasman 1 Multiple Endocrine Neoplasia Type 1 (MEN 1) kindred, researchers characterized the effect of unrecognized and untreated MEN 1 on fertility and pregnancy outcomes. All MEN 1 positive (MEN 1⁺, n=63) and MEN 1 negative (MEN 1^-, n=75) descendants born between 1825 and 1951 of a common founder were included. It was noted that MEN 1⁺ parents had more children and live births with no excess of stillbirths compared to MEN 1^- parents. Findings revealed that MEN 1⁺ parents had a similar number of MEN 1⁺ and MEN 1^- offspring. They did not find any adverse impact of MEN 1 on patient fertility overall. However, in a subset of patients with pituitary disease, MEN 1-related pathology might impair reproductive potential.