Charlson F, et al. - Via a systematic review and meta-analysis of studies published between January 1, 2000, and August 9, 2017, researchers intended to update WHO estimates for the prevalence of mental disorders in conflict-affected settings and estimate the burden per 1,000 population. At any point in time in the conflict-affected populations evaluated, the prevalence of mental disorders (depression, anxiety, post-traumatic stress disorder, bipolar disorder, and schizophrenia) was 22.1 %. For mild forms of depression, anxiety, and post-traumatic stress disorder and for moderate forms, the mean comorbidity-adjusted, age-standardized point prevalence was 13.0% and 4.0%, respectively. For severe disorders like schizophrenia, bipolar disorder, severe depression, severe anxiety, and severe post-traumatic stress disorder, the mean comorbidity-adjusted, age-standardized point prevalence was 5.1%. In conflict-affected populations, the burden of mental disorders is high, and an scalable mental health interventions to address this burden was is urgently needed, given the large numbers of people impacted and the humanitarian imperative to decrease suffering.