Gil MM, Molina FS, Rodríguez‐Fernández M, et al. - In this retrospective cohort study, researchers investigated the risk of miscarriage linked with chorionic villus sampling (CVS). They performed inclusion of two populations of women attending for routine ultrasound examination at 11 + 0 to 13 + 6 weeks' gestation at one of eight fetal‐medicine units in Spain, Belgium and Bulgaria, between July 2007 and June 2018: (1) all singleton pregnancies undergoing first‐trimester assessment at Hospital Clínico Universitario Virgen de la Arrixaca in Murcia, Spain, that did not have CVS (non‐CVS group); and (2) all singleton pregnancies that underwent CVS following first‐trimester assessment at one of the eight participating centers (CVS group). Observations revealed nearly 1% higher risk of miscarriage in women undergoing CVS than women who do not have CVS, although the invasive procedure was not the sole contributor to this excess risk, the demographic and pregnancy characteristics of the patients also have contribution to some extent. After addressing these risk factors and confining the analysis to low‐risk pregnancies, CVS appears to raise the risk of miscarriage by about three times above the patient's background risk. Although this being a substantial raise in relative terms, the risk of miscarriage after CVS in pregnancies without risk factors for miscarriage remains low and similar to, or slightly greater than, that in the general population.