Kim M, Hwang WJ, Park J, et al. - Researchers here examined if patients with early psychosis exhibit altered neurophysiological responses related to emotion regulation by cognitive reappraisal. In event-related potential recordings during a validated emotion regulation paradigm, participants were 54 patients with first-episode psychosis (FEP), 34 individuals at clinical high risk (CHR) for psychosis, and 30 healthy controls (HCs), for determining the effect of cognitive reappraisal on emotion regulation. Comparably larger late positive potential (LPP) amplitudes, which reflect emotional arousal, were observed for the FEP and CHR participants in the negative and cognitive reappraisal conditions than in the neutral condition, whereas larger LPPs were observed in the HCs in the negative condition than in the cognitive reappraisal and neutral conditions. Negative correlation was observed of LPP modulation by cognitive reappraisal with positive symptom severity in the FEP patients and with disorganization severity in the CHR individuals. Per these findings, there may be a possible correlation of inefficient use of cognitive reappraisal with impaired emotion regulation and psychotic symptoms from the very beginning of psychotic disorder. This study yields the first neurophysiological evidence concerning current concepts of emotion regulation in early psychosis.